A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy

One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown...

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Veröffentlicht in:	British journal of cancer 2000-11, Vol.83 (9), p.1124-1127
Hauptverfasser:	Kohler, J A, Imeson, J, Ellershaw, C, Lie, S O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antineoplastic agents Antineoplastic Agents, Alkylating - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cheilitis - chemically induced Chemotherapy Child Child, Preschool Dose-Response Relationship, Drug Double-Blind Method Drug Resistance Epidemiology Follow-Up Studies Humans Infant Isotretinoin - adverse effects Isotretinoin - therapeutic use Medical sciences Melphalan - therapeutic use Molecular Medicine Neoplasm Staging Neoplasm, Residual - drug therapy Neoplasm, Residual - pathology Neuroblastoma - drug therapy Neuroblastoma - mortality Neuroblastoma - pathology Oncology Pharmacology. Drug treatments Regular regular-article Skin Diseases - chemically induced Survival Analysis Survival Rate Treatment Outcome
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Zusammenfassung:	One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown for the children receiving retinoic acid. © 2000 Cancer Research Campaign
ISSN:	0007-0920 1532-1827
DOI:	10.1054/bjoc.2000.1425