Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2
Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumo...
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| Veröffentlicht in: | British journal of cancer 2000-07, Vol.83 (2), p.177-183 |
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| creator | RAPLEY, E. A BARFOOT, R SKEEN, J DE TOURRELL, S WEIRICH, A PRITCHARD-JONES, K STRATTON, M. R RAHMAN, N BONAÏTI-PELLIE, C CHOMPRET, A FOULKES, W PERUSINGHE, N REEVE, A ROYER-POKORA, B SCHUMACHER, V SHELLING, A |
| description | Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found. |
| doi_str_mv | 10.1054/bjoc.2000.1283 |
| format | Article |
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A ; BARFOOT, R ; SKEEN, J ; DE TOURRELL, S ; WEIRICH, A ; PRITCHARD-JONES, K ; STRATTON, M. R ; RAHMAN, N ; BONAÏTI-PELLIE, C ; CHOMPRET, A ; FOULKES, W ; PERUSINGHE, N ; REEVE, A ; ROYER-POKORA, B ; SCHUMACHER, V ; SHELLING, A</creator><creatorcontrib>RAPLEY, E. A ; BARFOOT, R ; SKEEN, J ; DE TOURRELL, S ; WEIRICH, A ; PRITCHARD-JONES, K ; STRATTON, M. R ; RAHMAN, N ; BONAÏTI-PELLIE, C ; CHOMPRET, A ; FOULKES, W ; PERUSINGHE, N ; REEVE, A ; ROYER-POKORA, B ; SCHUMACHER, V ; SHELLING, A</creatorcontrib><description>Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1054/bjoc.2000.1283</identifier><identifier>PMID: 10901367</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Biological and medical sciences ; Cancer research ; chromosome 11 ; chromosome 17 ; chromosome 19 ; Chromosomes ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 17 ; DNA-Binding Proteins - genetics ; Female ; FWT1 gene ; Genes ; Genetic Linkage ; Genetic Markers ; Genetic Predisposition to Disease ; Genetics ; Hospitals ; Humans ; Kidneys ; Kinases ; Male ; Medical research ; Medical sciences ; Mutation ; Nephrology. Urinary tract diseases ; Pedigree ; Regular ; Transcription Factors - genetics ; Tumors of the urinary system ; Wilms Tumor - genetics ; Wilms' tumor ; WT1 gene ; WT1 Proteins</subject><ispartof>British journal of cancer, 2000-07, Vol.83 (2), p.177-183</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jul 2000</rights><rights>Copyright © 2000 Cancer Research Campaign 2000 Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-797c55d0781da7726ff156ac5f3e9afb5c021cc4a15bb6f18e2cb76e5b3d34bf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363495/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363495/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1412726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10901367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RAPLEY, E. A</creatorcontrib><creatorcontrib>BARFOOT, R</creatorcontrib><creatorcontrib>SKEEN, J</creatorcontrib><creatorcontrib>DE TOURRELL, S</creatorcontrib><creatorcontrib>WEIRICH, A</creatorcontrib><creatorcontrib>PRITCHARD-JONES, K</creatorcontrib><creatorcontrib>STRATTON, M. 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Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found.</description><subject>Biological and medical sciences</subject><subject>Cancer research</subject><subject>chromosome 11</subject><subject>chromosome 17</subject><subject>chromosome 19</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Chromosomes, Human, Pair 17</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>FWT1 gene</subject><subject>Genes</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Kinases</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Pedigree</subject><subject>Regular</subject><subject>Transcription Factors - genetics</subject><subject>Tumors of the urinary system</subject><subject>Wilms Tumor - genetics</subject><subject>Wilms' tumor</subject><subject>WT1 gene</subject><subject>WT1 Proteins</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFks9rFTEQx4Mo9lm9epQgohf3mcmPzeYiSGlVKHip9CKEbDapeewmz2S30P_eLO-h1YNekpnJZwbynS9Cz4FsgQj-rt8lu6WE1JR27AHagGC0gY7Kh2hTy7IhipIT9KSUXU0V6eRjdAI1ANbKDfp2fhsGF63DPmVclmLdfg59GMN8h29cdAXPCXsz1YoZ8XUYp1pZprRkHCI2wxDmkOIKXV_BW3xRT2zisAb0KXrkzVjcs-N9ir5enF-dfWouv3z8fPbhsrGCiLmRSlohBiI7GIyUtPUeRGus8Mwp43thCQVruQHR962HzlHby9aJng2M956doveHufuln9xgXZyzGfU-h8nkO51M0H--xPBd36RbTVnLuBJ1wJvjgJx-LK7MegpViXE00aWl6E4p4FVMVsnX_yQlUE55J_8LghSCA7QVfPkXuKvixqqXplQp2UkJFdoeIJtTKdn5X58Dolcj6NUIejWCXo1QG17cl-Qefth8BV4dAVOsGX020Ybym-NA6ybYTztauvk</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>RAPLEY, E. 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A</au><au>BARFOOT, R</au><au>SKEEN, J</au><au>DE TOURRELL, S</au><au>WEIRICH, A</au><au>PRITCHARD-JONES, K</au><au>STRATTON, M. R</au><au>RAHMAN, N</au><au>BONAÏTI-PELLIE, C</au><au>CHOMPRET, A</au><au>FOULKES, W</au><au>PERUSINGHE, N</au><au>REEVE, A</au><au>ROYER-POKORA, B</au><au>SCHUMACHER, V</au><au>SHELLING, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2</atitle><jtitle>British journal of cancer</jtitle><addtitle>Br J Cancer</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>83</volume><issue>2</issue><spage>177</spage><epage>183</epage><pages>177-183</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>10901367</pmid><doi>10.1054/bjoc.2000.1283</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Cancer research chromosome 11 chromosome 17 chromosome 19 Chromosomes Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 17 DNA-Binding Proteins - genetics Female FWT1 gene Genes Genetic Linkage Genetic Markers Genetic Predisposition to Disease Genetics Hospitals Humans Kidneys Kinases Male Medical research Medical sciences Mutation Nephrology. Urinary tract diseases Pedigree Regular Transcription Factors - genetics Tumors of the urinary system Wilms Tumor - genetics Wilms' tumor WT1 gene WT1 Proteins |
| title | Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2 |
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