Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2

Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumo...

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Veröffentlicht in:	British journal of cancer 2000-07, Vol.83 (2), p.177-183
Hauptverfasser:	RAPLEY, E. A, BARFOOT, R, SKEEN, J, DE TOURRELL, S, WEIRICH, A, PRITCHARD-JONES, K, STRATTON, M. R, RAHMAN, N, BONAÏTI-PELLIE, C, CHOMPRET, A, FOULKES, W, PERUSINGHE, N, REEVE, A, ROYER-POKORA, B, SCHUMACHER, V, SHELLING, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cancer research chromosome 11 chromosome 17 chromosome 19 Chromosomes Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 17 DNA-Binding Proteins - genetics Female FWT1 gene Genes Genetic Linkage Genetic Markers Genetic Predisposition to Disease Genetics Hospitals Humans Kidneys Kinases Male Medical research Medical sciences Mutation Nephrology. Urinary tract diseases Pedigree Regular Transcription Factors - genetics Tumors of the urinary system Wilms Tumor - genetics Wilms' tumor WT1 gene WT1 Proteins
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Zusammenfassung:	Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found.
ISSN:	0007-0920 1532-1827
DOI:	10.1054/bjoc.2000.1283