The human herpesvirus-type 8 is not involved in malignant melanoma

Malignant melanomas were supposed to harbour the human herpesvirus-type 8 (HHV-8) genome, as melanoma cells were reported to express interleukin-6 and a homologue of interleukin-6 was found in the HHV-8 genome. We therefore investigated 33 primary malignant melanomas by polymerase chain reaction, bu...

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Veröffentlicht in:	British Journal of Cancer 1999-04, Vol.80 (1-2), p.67-69
Hauptverfasser:	Deichmann, M, Thome, M, Bock, M, Jäckel, A, Waldmann, V, Näher, H
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Dermatology DNA, Viral - isolation & purification Drug Resistance Epidemiology Herpesvirus 8, Human - genetics Herpesvirus 8, Human - isolation & purification Humans Interleukin-6 - genetics Medical sciences Melanoma - pathology Melanoma - virology Molecular Medicine Oncology Polymerase Chain Reaction Short Communication Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:	Malignant melanomas were supposed to harbour the human herpesvirus-type 8 (HHV-8) genome, as melanoma cells were reported to express interleukin-6 and a homologue of interleukin-6 was found in the HHV-8 genome. We therefore investigated 33 primary malignant melanomas by polymerase chain reaction, but could not find this tumorigenic gamma-herpesvirus in any tumour.
ISSN:	0007-0920 1476-5381 1532-1827
DOI:	10.1038/sj.bjc.6690322