The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations

Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome...

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Veröffentlicht in:	British journal of cancer 2005-05, Vol.92 (9), p.1599-1610
Hauptverfasser:	Leach, M O, Brindle, K M, Evelhoch, J L, Griffiths, J R, Horsman, M R, Jackson, A, Jayson, G C, Judson, I R, Knopp, M V, Maxwell, R J, McIntyre, D, Padhani, A R, Price, P, Rathbone, R, Rustin, G J, Tofts, P S, Tozer, G M, Vennart, W, Waterton, J C, Williams, S R, Workman, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - therapeutic use Antineoplastic Agents - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Clinical Trials as Topic clinical-study Drug Resistance Epidemiology Evaluation Studies as Topic Magnetic Resonance Imaging Medical sciences Molecular Medicine Neoplasms - blood supply Neoplasms - drug therapy Oncology Reproducibility of Results Terminology as Topic Tumors Workshop Report
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Zusammenfassung:	Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that considered the methodology and design of magnetic resonance studies, recommending how this new tool might best be used.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6602550