CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea

In a nested-case control study of 100 cases of gastric cancer and 400 matched controls in relation to virulence factors of Helicobacter pylori in a Korean cohort, CagA seropositivity was significantly associated with a higher risk of gastric cancer among H. pylori-infected subjects (OR=3.57, 95% CI...

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Veröffentlicht in:	British journal of cancer 2006-09, Vol.95 (5), p.639-641
Hauptverfasser:	Gwack, J, Shin, A, Kim, C-S, Ko, K-P, Kim, Y, Jun, J K, Bae, J, Park, S K, Hong, Y-C, Kang, D, Chang, S-H, Shin, H-R, Yoo, K-Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alcohol Drinking Antigens, Bacterial Bacterial Proteins Case-Control Studies Female Helicobacter Infections - complications Helicobacter Infections - epidemiology Helicobacter pylori Helicobacter pylori - genetics Helicobacter pylori - isolation & purification Helicobacter pylori - pathogenicity Humans Korea - epidemiology Male Middle Aged Risk Factors Short Communication Smoking Stomach Neoplasms - epidemiology Stomach Neoplasms - microbiology Virulence
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Zusammenfassung:	In a nested-case control study of 100 cases of gastric cancer and 400 matched controls in relation to virulence factors of Helicobacter pylori in a Korean cohort, CagA seropositivity was significantly associated with a higher risk of gastric cancer among H. pylori-infected subjects (OR=3.57, 95% CI 1.05-12.14).
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6603309