Network-based analysis of calcium-binding protein genes identifies Grp94 as a target in human oral carcinogenesis

To characterise Ca 2+ -binding protein gene expression changes in oral squamous cell carcinomas (OSCCs), we compared the gene expression profiles in OSCC-derived cell lines with normal oral tissues. One hundred Ca 2+ -binding protein genes differentially expressed in OSCCs were identified, and genet...

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Veröffentlicht in:	British journal of cancer 2007-09, Vol.97 (6), p.792-801
Hauptverfasser:	Nomura, H, Uzawa, K, Yamano, Y, Fushimi, K, Ishigami, T, Kato, Y, Saito, K, Nakashima, D, Higo, M, Kouzu, Y, Ono, K, Ogawara, K, Shiiba, M, Bukawa, H, Yokoe, H, Tanzawa, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Calcium-Binding Proteins - genetics Cancer Research Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Line, Tumor Disease-Free Survival Drug Resistance Epidemiology Fluorescent Antibody Technique, Direct Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Kaplan-Meier Estimate Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Molecular Diagnostics Molecular Medicine Mouth Neoplasms - drug therapy Mouth Neoplasms - genetics Mouth Neoplasms - pathology Neoplasm Staging Oncology Otorhinolaryngology. Stomatology Predictive Value of Tests Prognosis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Tumors Up-Regulation Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Zusammenfassung:	To characterise Ca 2+ -binding protein gene expression changes in oral squamous cell carcinomas (OSCCs), we compared the gene expression profiles in OSCC-derived cell lines with normal oral tissues. One hundred Ca 2+ -binding protein genes differentially expressed in OSCCs were identified, and genetic pathways associated with expression changes were generated. Among genes mapped to the network with the highest significance, glucose-regulated protein 94 kDa (Grp94) was evaluated further for mRNA and protein expression in the OSCC cell lines, primary OSCCs, and oral premalignant lesions (OPLs). A significant ( P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6603948