De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis

This study investigated sonic hedgehog (Shh) signalling in gastric metaplasia in the insulin-gastrin (InsGas) hypergastrinaemic mouse +/- Helicobacter felis (H. felis) infection. Sonic hedgehog gene and protein expression was reduced in pre-metaplastic lesions from non-infected mice (90% gene reduct...

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Veröffentlicht in:	British journal of cancer 2007-06, Vol.96 (12), p.1855-1861
Hauptverfasser:	EI-ZAATARI, M, TOBIAS, A, GRABOWSKA, A. M, KUMARI, R, SCOTTING, P. J, KAYE, P, ATHERTON, J, CLARKE, P. A, POWE, D. G, WATSON, S. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animals Antibodies Biological and medical sciences Cancer research Cell Line, Tumor Felis Gastric cancer Gastric Mucosa - pathology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Hedgehog Proteins - genetics Helicobacter felis Humans Infections Medical research Medical sciences Mice Mice, Inbred Strains Neoplasms, Experimental - genetics Neoplasms, Experimental - pathology Polymerase Chain Reaction Precancerous Conditions - genetics Precancerous Conditions - pathology Proteins Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Translational Therapeutics Tumors
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Zusammenfassung:	This study investigated sonic hedgehog (Shh) signalling in gastric metaplasia in the insulin-gastrin (InsGas) hypergastrinaemic mouse +/- Helicobacter felis (H. felis) infection. Sonic hedgehog gene and protein expression was reduced in pre-metaplastic lesions from non-infected mice (90% gene reduction, P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6603782