Sex hormone levels correlate with the activity of cytokine‐secreting cells in vivo

Sex hormone levels correlate with the activity of cytokine‐secreting cells in vivo

Summary This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA‐S) and the number of human peripheral blood cells actively secreting interleukin (IL)‐2, IL‐4, IL‐6, IL‐10, tumour necrosis factor‐α (TNF‐α) or interferon‐γ (IFN‐γ) in...

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Veröffentlicht in:Immunology 2000-07, Vol.100 (3), p.384-390
Hauptverfasser: Verthelyi, D., Klinman, D. M.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Cytokines - blood
dehydroepiandrosterone
Dehydroepiandrosterone Sulfate - blood
Estradiol - blood
estrogens
Female
g-Interferon
Gonadal Steroid Hormones - blood
Humans
Interferon-gamma - blood
Interleukin-4 - blood
Interleukins - blood
Male
Menstrual Cycle - immunology
Middle Aged
Original
Postmenopause - immunology
Premenopause - immunology
progesterone
Progesterone - blood
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Zusammenfassung:Summary This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA‐S) and the number of human peripheral blood cells actively secreting interleukin (IL)‐2, IL‐4, IL‐6, IL‐10, tumour necrosis factor‐α (TNF‐α) or interferon‐γ (IFN‐γ) in vivo. Simultaneous assessment of serum hormone levels and cytokine‐secreting cell activity throughout the menstrual cycle showed that the number of peripheral blood mononuclear cells (PBMC) able to secrete IL‐4 in response to stimulation correlated significantly (P 
ISSN:0019-2805
1365-2567
DOI:10.1046/j.1365-2567.2000.00047.x