Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma

Medulloblastoma is an embryonal tumor thought to arise from the granule cell precursors (GCPs) of the cerebellum. PATCHED (PTCH), an inhibitor of Hedgehog signaling, is the best-characterized tumor suppressor in medulloblastoma. However,

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Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 2008-03, Vol.22 (6), p.770-785
Hauptverfasser:	Briggs, Kimberly J, Corcoran-Schwartz, Ian M, Zhang, Wei, Harcke, Thomas, Devereux, Wendy L, Baylin, Stephen B, Eberhart, Charles G, Watkins, D Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cerebellar Neoplasms - etiology Cerebellar Neoplasms - pathology Cerebellum - cytology Cerebellum - metabolism Chromatin Immunoprecipitation Female Fibroblasts - cytology Fibroblasts - metabolism Fluorescent Antibody Technique Gene Expression Profiling Gene Silencing Genes, Tumor Suppressor Humans Immunoenzyme Techniques Kruppel-Like Transcription Factors - physiology Male Medulloblastoma - etiology Medulloblastoma - pathology Mice Mice, Inbred C57BL Mice, Knockout Oligonucleotide Array Sequence Analysis Patched Receptors Patched-1 Receptor Receptors, Cell Surface - physiology Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Sirtuin 1 Sirtuins Transfection
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Beschreibung
Zusammenfassung:	Medulloblastoma is an embryonal tumor thought to arise from the granule cell precursors (GCPs) of the cerebellum. PATCHED (PTCH), an inhibitor of Hedgehog signaling, is the best-characterized tumor suppressor in medulloblastoma. However,
ISSN:	0890-9369 1549-5477
DOI:	10.1101/gad.1640908