Inhalational Anesthetics as Neuroprotectants or Chemical Preconditioning Agents in Ischemic Brain

This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical s...

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Veröffentlicht in:	Journal of Cerebral Blood Flow & Metabolism 2007-06, Vol.27 (6), p.1108-1128
Hauptverfasser:	Kitano, Hideto, Kirsch, Jeffrey R, Hurn, Patricia D, Murphy, Stephanie J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Inhalation - pharmacology Anesthetics, Inhalation - therapeutic use Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain Ischemia - drug therapy Humans Investigative techniques, diagnostic techniques (general aspects) Ischemic Preconditioning - methods Medical sciences Nervous system Neurology Neuroprotective Agents - therapeutic use Pharmacology. Drug treatments Ultrasonic investigative techniques Vascular diseases and vascular malformations of the nervous system
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Beschreibung
Zusammenfassung:	This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.
ISSN:	0271-678X 1559-7016
DOI:	10.1038/sj.jcbfm.9600410