Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma

Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence inte...

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Veröffentlicht in:	British journal of cancer 2008-02, Vol.98 (4), p.689-692
Hauptverfasser:	Früh, M, Zhou, W, Zhai, R, Su, L, Heist, R S, Wain, J C, Nishioka, N S, Lynch, T J, Shepherd, F A, Christiani, D C, Liu, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adenocarcinoma - virology Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - virology Case-Control Studies Drug Resistance Epidemiology Esophageal Neoplasms - epidemiology Esophageal Neoplasms - genetics Esophageal Neoplasms - virology Female Genotype Helicobacter Infections - epidemiology Helicobacter Infections - genetics Helicobacter Infections - virology Helicobacter pylori Helicobacter pylori - genetics Helicobacter pylori - immunology Human bacterial diseases Humans Infectious diseases Male Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 12 - genetics Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 3 - genetics Medical sciences Middle Aged Molecular Medicine Oncology Polymerase Chain Reaction Polymorphism, Genetic - genetics Short Communication Surveys and Questionnaires Tumors
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Zusammenfassung:	Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1–0.7). Matrix metalloproteinases may modulate the EA–HP relationship.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6604234