Targeting telomerase for cancer therapeutics

One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeut...

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Veröffentlicht in:	British journal of cancer 2008-02, Vol.98 (4), p.677-683
Hauptverfasser:	Shay, J W, Keith, W N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Biological and medical sciences Biology Biomedical and Life Sciences Biomedicine Cancer Research Cell death Cell division Cell growth Chromosomes Clinical trials DNA damage Drug Resistance Epidemiology Gene therapy Humans Immunotherapy Medical research Medical sciences mini-review Minireview Molecular Medicine Neoplasms - enzymology Neoplasms - therapy Oncology Pharmacodynamics Senescence Telomerase Telomerase - antagonists & inhibitors Telomerase - metabolism Tumors
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Beschreibung
Zusammenfassung:	One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6604209