The neurobiology and genetics of impulse control disorders: Relationships to drug addictions

Impulse control disorders (ICDs), including pathological gambling, trichotillomania, kleptomania and others, have been conceptualized to lie along an impulsive–compulsive spectrum. Recent data have suggested that these disorders may be considered addictions. Here, we review the genetic and neuropath...

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Veröffentlicht in:	Biochemical pharmacology 2008-01, Vol.75 (1), p.63-75
Hauptverfasser:	Brewer, Judson A., Potenza, Marc N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Animals Brain imaging Decision Making Disruptive, Impulse Control, and Conduct Disorders - etiology Disruptive, Impulse Control, and Conduct Disorders - genetics Dopamine - physiology Endorphins - physiology gamma-Aminobutyric Acid - physiology Genetics Genetics, Population Glutamic Acid - physiology Humans Impulse control disorders Impulsive Behavior Pathological gambling Prefrontal Cortex - physiology Reward Stress, Psychological - complications Substance-Related Disorders - etiology Substance-Related Disorders - genetics
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Beschreibung
Zusammenfassung:	Impulse control disorders (ICDs), including pathological gambling, trichotillomania, kleptomania and others, have been conceptualized to lie along an impulsive–compulsive spectrum. Recent data have suggested that these disorders may be considered addictions. Here, we review the genetic and neuropathological bases of the impulse control disorders and consider the disorders within these non-mutually exclusive frameworks.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/j.bcp.2007.06.043