Tetramethylpyridiniumporphyrazines--a new class of G-quadruplex inducing and stabilising ligands

Tetramethylpyridiniumporphyrazines--a new class of G-quadruplex inducing and stabilising ligands

3,4-Tetramethylpyridiniumporphyrazines bind strongly and selectively to human telomeric G-quadruplex DNA, inducing the formation of an antiparallel quadruplex in a process that mimics molecular chaperones.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2006-01 (45), p.4685-4687
Hauptverfasser: Gonçalves, Diana P N, Rodriguez, Raphaël, Balasubramanian, Shankar, Sanders, Jeremy K M
Format: Artikel
Sprache:eng
Schlagworte:
chemical reactions
DNA
DNA - chemistry
G-Quadruplexes
humans
Ligands
Methylation
molecular chaperones
Molecular Structure
Porphyrins - chemistry
Pyridines - chemistry
Spectrum Analysis
telomeres
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:3,4-Tetramethylpyridiniumporphyrazines bind strongly and selectively to human telomeric G-quadruplex DNA, inducing the formation of an antiparallel quadruplex in a process that mimics molecular chaperones.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/b611731g