Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation

The specific intracellular sites at which enzymes act to generate arachidonate-derived eicosanoid mediators of inflammation are uncertain. We evaluated the formation and function of cytoplasmic lipid bodies. Lipid body formation in eosinophils was a rapidly (

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 1997-09, Vol.186 (6), p.909-920
Hauptverfasser:	Bozza, P T, Yu, W, Penrose, J F, Morgan, E S, Dvorak, A M, Weller, P F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arachidonate 5-Lipoxygenase - metabolism Binding Sites Cell Nucleus - metabolism Eicosanoids - biosynthesis Enzyme Inhibitors - pharmacology Eosinophils - drug effects Eosinophils - metabolism Eosinophils - ultrastructure Glutathione Transferase - metabolism Humans Immunohistochemistry In Vitro Techniques Inclusion Bodies - drug effects Inclusion Bodies - metabolism Inclusion Bodies - ultrastructure Inflammation Mediators - metabolism Lipid Metabolism Platelet Activating Factor - pharmacology Prostaglandin-Endoperoxide Synthases - metabolism Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Synthesis Inhibitors - pharmacology Signal Transduction
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Zusammenfassung:	The specific intracellular sites at which enzymes act to generate arachidonate-derived eicosanoid mediators of inflammation are uncertain. We evaluated the formation and function of cytoplasmic lipid bodies. Lipid body formation in eosinophils was a rapidly (
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.186.6.909