Recombinant interleukin 4 suppresses the production of interferon γ by human mononuclear cells

rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production...

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Veröffentlicht in:	The Journal of experimental medicine 1989-11, Vol.170 (5), p.1751-1756
Hauptverfasser:	PELEMAN, R, WU, J, FARGEAS, C, DELESPESSE, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Blotting, Northern Cells, Cultured Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunoglobulin E - biosynthesis In Vitro Techniques Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-4 - pharmacology Leukocytes, Mononuclear - metabolism Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphokines, interleukins ( function, expression) Mitogens - pharmacology Regulatory factors and their cellular receptors RNA, Messenger - metabolism
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Beschreibung
Zusammenfassung:	rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production of IL-4 and IFN-gamma may be significantly influenced by the chronological order of activation of their respective gene.
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.170.5.1751