Newcastle disease virus-infected splenocytes express the proopiomelanocortin gene

Infection of murine splenocytes with Newcastle disease virus results in expression of the proopiomelanocortin gene as determined by dot and northern blot analysis of total cellular and poly(A)+ cytoplasmic RNA. These data provide the first evidence that the precursor protein for adrenocorticotropin...

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Veröffentlicht in:	The Journal of experimental medicine 1986-06, Vol.163 (6), p.1589-1594
Hauptverfasser:	WESTLY, H. J, KLEISS, A. J, KELLEY, K. W, WONG, P. K. Y, PICK-HOONG YUEN
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - biosynthesis Adrenocorticotropic Hormone - metabolism Analysis of the immune response. Humoral and cellular immunity Animals beta-Endorphin Biological and medical sciences Endorphins - biosynthesis Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Immunobiology Lymphocytes - metabolism Mice Mice, Inbred BALB C Newcastle disease virus Newcastle disease virus - physiology Organs and cells involved in the immune response Poly A - analysis Pro-Opiomelanocortin - biosynthesis Pro-Opiomelanocortin - genetics RNA, Messenger - analysis Spleen - cytology Spleen - metabolism
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Zusammenfassung:	Infection of murine splenocytes with Newcastle disease virus results in expression of the proopiomelanocortin gene as determined by dot and northern blot analysis of total cellular and poly(A)+ cytoplasmic RNA. These data provide the first evidence that the precursor protein for adrenocorticotropin and beta-endorphin can be synthesized by lymphoid cells.
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.163.6.1589