Compartmentalized regulation of macrophage arachidonic acid metabolism

We show that downregulation of arachidonic acid (20:4) metabolism which occurs following i.p. injection of C. parvum can occur in a single, localized macrophage population, and is therefore unlikely to be mediated solely by a systemic factor.

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 1986-03, Vol.163 (3), p.752-757
Hauptverfasser:	FELS, A. O. S, PAWLOWSKI, N. A, ABRAHAM, E. L, COHN, Z. A
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - metabolism Animals Arachidonic Acid Arachidonic Acids - metabolism Biological and medical sciences Dinoprostone Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Inflammation - metabolism Macrophages - metabolism Mice Myeloid cells: ontogeny, maturation, markers, receptors Phospholipids - metabolism Prostaglandins E - metabolism SRS-A - metabolism Thromboxane B2 - metabolism
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Beschreibung
Zusammenfassung:	We show that downregulation of arachidonic acid (20:4) metabolism which occurs following i.p. injection of C. parvum can occur in a single, localized macrophage population, and is therefore unlikely to be mediated solely by a systemic factor.
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.163.3.752