A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective

A multivalent lacto-N-fucopentaose (LNFP) III-lysyllysine conjugate was observed to decompact preimplantation mouse embryos. Decompaction was not obtained with free oligosaccharides (LNFP II and III), nor with multivalent LNFP II-lysyllysine or chitotriose-lysyllysine conjugates. These results sugge...

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Veröffentlicht in:	The Journal of experimental medicine 1984-11, Vol.160 (5), p.1591-1596
Hauptverfasser:	FENDERSON, B. A, ZEHAVI, U, HAKOMORI, S.-I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blastocyst - drug effects Blastocyst - physiology Cell Adhesion - drug effects Cell Communication - drug effects Cell differentiation, maturation, development, hematopoiesis Cell physiology Dipeptides - physiology Embryonic and Fetal Development - drug effects Female Fundamental and applied biological sciences. Psychology Haptens - physiology Humans Lewis X Antigen - physiology Mice Molecular and cellular biology Pregnancy
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Beschreibung
Zusammenfassung:	A multivalent lacto-N-fucopentaose (LNFP) III-lysyllysine conjugate was observed to decompact preimplantation mouse embryos. Decompaction was not obtained with free oligosaccharides (LNFP II and III), nor with multivalent LNFP II-lysyllysine or chitotriose-lysyllysine conjugates. These results suggest a role for X hapten recognition during compaction and suggest further that X hapten valency may play a key role in modulating this developmental process.
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.160.5.1591