PAF activation of a voltage‐gated R‐type Ca2+ channel in human and canine aortic endothelial cells
By the use of fura‐2 and digital imaging techniques, [K]o depolarization or PAF (10−9 m) were shown to induce a sustained increase of [Ca]i in human or canine single aortic vascular endothelial cells (VEC) that was insensitive to nifedipine but sensitive to (−)‐PN200–110 or to lowering of [Ca]o. The...
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Veröffentlicht in: | British journal of pharmacology 1993-10, Vol.110 (2), p.519-520 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | By the use of fura‐2 and digital imaging techniques, [K]o depolarization or PAF (10−9 m) were shown to induce a sustained increase of [Ca]i in human or canine single aortic vascular endothelial cells (VEC) that was insensitive to nifedipine but sensitive to (−)‐PN200–110 or to lowering of [Ca]o. The PAF‐induced effect on [Ca]i was blocked by the PAF receptor antagonist, WEB2170. Our results suggest that [K]o depolarization and PAF increase [Ca]i via the activation of R‐type Ca2+ channels. |
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ISSN: | 0007-1188 1476-5381 |
DOI: | 10.1111/j.1476-5381.1993.tb13841.x |