Actin Turnover Is Required to Prevent Axon Retraction Driven by Endogenous Actomyosin Contractility

Growth cone motility and guidance depend on the dynamic reorganization of filamentous actin (F-actin). In the growth cone, F-actin undergoes turnover, which is the exchange of actin subunits from existing filaments. However, the function of F-actin turnover is not clear. We used jasplakinolide (jasp...

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Veröffentlicht in:	The Journal of cell biology 2002-09, Vol.158 (7), p.1219-1228
Hauptverfasser:	Gallo, Gianluca, Yee, Hal F., Letourneau, Paul C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - drug effects Actin Cytoskeleton - metabolism Actins Actins - metabolism Actomyosin - metabolism Actomyosin - pharmacology Animals Antibodies Antineoplastic Agents - pharmacology Axons Axons - drug effects Axons - physiology Cells, Cultured Cellular biology Chick Embryo - cytology Chick Embryo - drug effects Chick Embryo - metabolism Depolymerization Depsipeptides Ephrin-A2 - pharmacology Fibroblasts Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Growth cones Growth Cones - drug effects Growth Cones - metabolism Immunoenzyme Techniques Intracellular Signaling Peptides and Proteins Microinjections Microscopy, Video Microtubules Microtubules - drug effects Microtubules - metabolism Myosin-Light-Chain Kinase - antagonists & inhibitors Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Peptides Peptides, Cyclic - pharmacology Phalloidine - pharmacology Phosphorylation Physiological regulation Protein Binding - drug effects Protein-Serine-Threonine Kinases - antagonists & inhibitors Proteins Retina - cytology Retina - drug effects Retina - metabolism rho-Associated Kinases rhoA GTP-Binding Protein - metabolism
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