FAK and Paxillin: Regulators of N-Cadherin Adhesion and Inhibitors of Cell Migration?

FAK and Paxillin: Regulators of N-Cadherin Adhesion and Inhibitors of Cell Migration?

FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell-matrix and cell-cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to t...

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Veröffentlicht in:The Journal of cell biology 2004-07, Vol.166 (2), p.157-159
1. Verfasser: Schaller, Michael D.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cadherins
Cadherins - metabolism
Cell Adhesion
Cell adhesion & migration
Cell motility
Cell Movement
Cells
Comment
Cytoskeletal Proteins - physiology
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Focal adhesions
HeLa cells
Humans
Paxillin
Phenotypes
Phosphoproteins - physiology
Physiological regulation
Protein-Tyrosine Kinases - physiology
Proteins
Racism
Reviews
Signal Transduction
Small interfering RNA
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Zusammenfassung:FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell-matrix and cell-cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to their established roles in several cell systems as positive regulators of cell adhesion and migration.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.200406151