Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis

The neurofilament protein is a major structural protein of neurons and a marker for axonal damage. The concentrations of the light subunit of the neurofilament triplet protein (NFL) in CSF were significantly increased in patients with relapsing-remitting multiple sclerosis compared with healthy cont...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1998-03, Vol.64 (3), p.402-404
Hauptverfasser:	Lycke, J N, Karlsson, J-E, Andersen, O, Rosengren, L E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer's disease Axons - pathology Biological and medical sciences Biomarkers - cerebrospinal fluid Case-Control Studies cerebrospinal fluid Diagnostic tests Disease Disease Progression Humans marker of disease activity Medical sciences Middle Aged Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis neurofilament Neurofilament Proteins - cerebrospinal fluid Neurology Neuropathology Proteins Recurrence Remission, Spontaneous Severity of Illness Index Short Report Spectrum analysis Time Factors
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Zusammenfassung:	The neurofilament protein is a major structural protein of neurons and a marker for axonal damage. The concentrations of the light subunit of the neurofilament triplet protein (NFL) in CSF were significantly increased in patients with relapsing-remitting multiple sclerosis compared with healthy controls (p
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.64.3.402