Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity

Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardioto...

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Veröffentlicht in:	British journal of cancer 1998-03, Vol.77 (6), p.973-977
Hauptverfasser:	Köhne, C-H, Thuss-Patience, P, Friedrich, M, Daniel, PT, Kretzschmar, A, Benter, T, Bauer, B, Dietz, R, Dörken, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - secondary Antimetabolites, Antineoplastic - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research clinical-oncology Drug Resistance Electrocardiography - drug effects Epidemiology Female Fluorouracil - adverse effects Gastroenterology. Liver. Pancreas. Abdomen Heart - drug effects Humans Liver Neoplasms - drug therapy Liver Neoplasms - secondary Lung Neoplasms - drug therapy Lung Neoplasms - secondary Male Medical sciences Middle Aged Molecular Medicine Oncology Quinazolines - therapeutic use Sigmoid Neoplasms - drug therapy Sigmoid Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thiophenes - therapeutic use Thymidylate Synthase - antagonists & inhibitors Tumors
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Zusammenfassung:	Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardiotoxicity. 5-FU cardiotoxicity is not due to the antineoplastic mechanisms via thymidilate synthase.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.1998.160