The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues

A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functi...

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Veröffentlicht in:	Protein science 1996-07, Vol.5 (7), p.1421-1425
Hauptverfasser:	Bork, Peer, Brown, Nigel P., Hegyi, Hedvig, Schultz, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	alignment Amino Acid Sequence Animals Bacteria - enzymology bacterial serine/threonine phosphatases homology search Humans Molecular Sequence Data Phosphoprotein Phosphatases - genetics Phylogeny PP2C Protein Phosphatase 2 Protein Phosphatase 2C Saccharomyces cerevisiae Proteins SpoIIE
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Zusammenfassung:	A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.
ISSN:	0961-8368 1469-896X
DOI:	10.1002/pro.5560050720