Knowledge‐based model building of proteins: Concepts and examples

We describe how to build protein models from structural templates. Methods to identify structural similarities between proteins in cases of significant, moderate to low, or virtually absent sequence similarity are discussed. The detection and evaluation of structural relationships is emphasized as a...

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Veröffentlicht in:Protein science 1993-11, Vol.2 (11), p.1798-1810
Hauptverfasser: Bajorath, Jürgen, Stenkamp, Ronald, Aruffo, Alejandro
Format: Artikel
Sprache:eng
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Zusammenfassung:We describe how to build protein models from structural templates. Methods to identify structural similarities between proteins in cases of significant, moderate to low, or virtually absent sequence similarity are discussed. The detection and evaluation of structural relationships is emphasized as a central aspect of protein modeling, distinct from the more technical aspects of model building. Computational techniques to generate and complement comparative protein models are also reviewed. Two examples, P‐selectin and gp39, are presented to illustrate the derivation of protein model structures and their use in experimental studies.
ISSN:0961-8368
1469-896X
DOI:10.1002/pro.5560021103