H-2-linked genetic control of immune responsiveness to ovalbumin and ovomucoid

Immune responsiveness of inbred mice to low doses of ovalbumin or ovomucoid is under control of single dominant genes closely linked to alleles of the H-2 locus. High responsiveness to ovomucoid is linked with the H-2(a) and H-2(k) alleles, and to ovalbumin with the H-2(b), H-2(d), and H-2(q) allele...

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Veröffentlicht in:	The Journal of experimental medicine 1971-11, Vol.134 (5), p.1335-1348
Hauptverfasser:	Vaz, N M, Phillips-Quagliata, J M, Levine, B B, Vaz, E M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Antibody Formation Female Genes, Dominant Histocompatibility Immunogenetics Inbreeding Isoantigens Mice Mucoproteins - administration & dosage Mucoproteins - pharmacology Ovalbumin - administration & dosage Ovalbumin - pharmacology Passive Cutaneous Anaphylaxis
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Beschreibung
Zusammenfassung:	Immune responsiveness of inbred mice to low doses of ovalbumin or ovomucoid is under control of single dominant genes closely linked to alleles of the H-2 locus. High responsiveness to ovomucoid is linked with the H-2(a) and H-2(k) alleles, and to ovalbumin with the H-2(b), H-2(d), and H-2(q) alleles.
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.134.5.1335