Laminin-Induced Clustering of Dystroglycan on Embryonic Muscle Cells: Comparison with Agrin-Induced Clustering

The effect of laminin on the distribution of dystroglycan (DG) and other surface proteins was examined by fluorescent staining in cultures of muscle cells derived from Xenopus embryos. Western blotting confirmed that previously characterized antibodies are reactive in Xenopus. In control cultures, α...

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Veröffentlicht in:	The Journal of cell biology 1997-03, Vol.136 (5), p.1047-1058
Hauptverfasser:	Cohen, Monroe W., Jacobson, Christian, Yurchenco, Peter D., Morris, Glenn E., Carbonetto, Salvatore
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Agrin - pharmacology Animals Antibodies Antibody Specificity Cells, Cultured Cellular biology Cholinergic receptors Cultured cells Cytoskeletal Proteins - analysis Cytoskeletal Proteins - chemistry Dystroglycans Dystrophin - analysis Embryos Fluorescent antibody techniques Humans Laminin - pharmacology Membrane Glycoproteins - analysis Membrane Glycoproteins - chemistry Membrane Proteins - analysis Molecules Muscle cells Muscle, Skeletal - chemistry Muscle, Skeletal - cytology Muscle, Skeletal - embryology Peptide Fragments - pharmacology Proteins Rabbits Receptors, Laminin - analysis Receptors, Laminin - chemistry Reptiles & amphibians Surface areas Synapses Utrophin Xenopus laevis
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Zusammenfassung:	The effect of laminin on the distribution of dystroglycan (DG) and other surface proteins was examined by fluorescent staining in cultures of muscle cells derived from Xenopus embryos. Western blotting confirmed that previously characterized antibodies are reactive in Xenopus. In control cultures, αDG, βDG, and laminin binding sites were distributed as microclusters (
ISSN:	0021-9525 1540-8140
DOI:	10.1083/jcb.136.5.1047