Regioselective double Suzuki couplings of 4,5-dibromothiophene-2-carboxaldehyde

Regioselective double Suzuki couplings of 4,5-dibromothiophene-2-carboxaldehyde

Conditions have been identified that enable the one-pot double Suzuki coupling of 4,5-dibromothiophene-2-carboxaldehyde to proceed in good yield. The key to success in these reactions is the use of minimal amounts of water to avoid significant amounts of dehalogenation during the first coupling.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2007-11, Vol.48 (46), p.8108-8110
Hauptverfasser: Handy, Scott T., Mayi, Diyar
Format: Artikel
Sprache:eng
Schlagworte:
Dehalogenation
One-pot
Regioselective
Suzuki coupling
Thiophenes
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Beschreibung
Zusammenfassung:Conditions have been identified that enable the one-pot double Suzuki coupling of 4,5-dibromothiophene-2-carboxaldehyde to proceed in good yield. The key to success in these reactions is the use of minimal amounts of water to avoid significant amounts of dehalogenation during the first coupling.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.09.114