Regulation of Scatter Factor Production via a Soluble Inducing Factor

Scatter factor (SF) (also known as hepatocyte growth factor [HGF]) is a fibroblast-derived cytokine that stimulates motility, proliferation, and morphogenesis of epithelia. SF may play major roles in development, repair, and carcinogenesis. However, the physiologic signals that regulate its producti...

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Veröffentlicht in:The Journal of cell biology 1994-10, Vol.127 (1), p.225-234
Hauptverfasser: Rosen, Eliot M., Joseph, Ansamma, Jin, Liang, Rockwell, Sara, Elias, Jack A., Knesel, Jaromir, Wines, James, McClellan, Jennifer, Kluger, M. J., Goldberg, Itzhak D., Zitnik, Ralph
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Sprache:eng
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Zusammenfassung:Scatter factor (SF) (also known as hepatocyte growth factor [HGF]) is a fibroblast-derived cytokine that stimulates motility, proliferation, and morphogenesis of epithelia. SF may play major roles in development, repair, and carcinogenesis. However, the physiologic signals that regulate its production are not well delineated. We found that various human tumor cell lines that do not produce SF secrete factors that stimulate SF production by fibroblasts, suggesting a paracrine mechanism for regulation of SF production. Conditioned medium from these cell lines contained two distinct scatter factor-inducing factor SF-IF activities: a high molecular weight (>30 kD), heat sensitive activity and a low molecular weight (
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.127.1.225