Mitochondrial disease mimicking Charcot–Marie Tooth disease

TableRepresentative nerve conduction studies of patients 1-3 Patient 1 Patient 2 Patient 3 Latency (ms) Amplitude (mV) C vel (m/S) Latency Amplitude Velocity Latency Amplitude Velocity Motor nerve conduction studies Peroneal nerve ankle-EDB Absent 7 1.6 7.1 0.7 Peroneal nerve knee-EDB 0.5 27 0.7 19 Tibial nerve ankle-AH Absent 7.3 2.2 6 8.2 Tibial nerve knee-AH 1.9 25 4.9 21 Median nerve wrist-APB 6.4 8.4 5.7 5.6 5.2 12.4 Median nerve elbow-APB 4.6 21 3.7 32 5.6 25 Sensory NCS Sural nerve Absent Absent Absent Median nerve wrist-index Absent 5.2 13 Absent Median nerve elbow-index 10.4 3 42 AH, abductor hallicus; APB, abductor pollicis brevis; C vel, conduction velocity; EDB, extensor digitorum brevis; NCS, nerve conduction studies. [...]young patients with CMT-like peripheral neuropathies and negative CMT genetic studies should undergo close clinical follow-up.