Profiling serum biomarkers in patients with COPD: associations with clinical parameters

Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with significant systemic consequences. Recognition of the systemic manifestations has stimulated interest in identifying circulating biomarkers in these patients. A systematic analysis was undertaken...

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Veröffentlicht in:	Thorax 2007-07, Vol.62 (7), p.595-601
Hauptverfasser:	Pinto-Plata, Victor, Toso, John, Lee, Kwan, Park, Daniel, Bilello, John, Mullerova, Hana, De Souza, Mary M, Vessey, Rupert, Celli, Bartolome
Format:	Artikel
Sprache:	eng
Schlagworte:	6-minute walk distance 6MWD amphiregulin BAL BDNF Biological and medical sciences Biomarkers Biomarkers - blood BMI BODE index Body Mass Index body mass index (B) brain-derived neurotropic factor bronchoalveolar lavage carbon monoxide transfer factor Case-Control Studies Chronic Obstructive Pulmonary Disease Chronic obstructive pulmonary disease, asthma COPD degree of obstruction (O) Discriminant analysis Dyspnea Emphysema false discovery adjusted p value FDR_p Female FEV1 Forced Expiratory Volume - physiology forced expiratory volume in 1 s Humans IFNγ interferon γ interleukin Lungs Male Medical sciences metalloproteinase Microarray Analysis - methods Middle Aged MMP nerve growth factor β partial least squares discriminant analysis Pathogenesis perception of dyspnoea (D) and exercise capacity (E) PLS-DA PMP Pneumology protein microarray platform Proteins Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - physiopathology RCA rolling cell amplification Smoking TGFα TIMP-1 tissue growth factor α tissue inhibitor of metalloproteinase 1 Tlco TNFα tumour necrosis factor α vascular endothelial growth factor VEGF βNGF
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Zusammenfassung:	Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with significant systemic consequences. Recognition of the systemic manifestations has stimulated interest in identifying circulating biomarkers in these patients. A systematic analysis was undertaken of multiple protein analytes in the serum of well characterised patients with COPD and matched controls using novel protein microarray platform (PMP) technology. Methods: Forty-eight patients (65% men) with COPD (forced expiratory volume in 1 s
ISSN:	0040-6376 1468-3296
DOI:	10.1136/thx.2006.064428