Brain Spectrin(240/235) and Brain Spectrin(240/235E): Two Distinct Spectrin Subtypes with Different Locations within Mammalian Neural Cells
Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic...
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| Veröffentlicht in: | The Journal of cell biology 1986-06, Vol.102 (6), p.2088-2097 |
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| container_end_page | 2097 |
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| container_issue | 6 |
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| container_title | The Journal of cell biology |
| container_volume | 102 |
| creator | Riederer, Beat M. Zagon, Ian S. Goodman, Steven R. |
| description | Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin(240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals. |
| doi_str_mv | 10.1083/jcb.102.6.2088 |
| format | Article |
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Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin(240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals.</description><identifier>ISSN: 0021-9525</identifier><identifier>EISSN: 1540-8140</identifier><identifier>DOI: 10.1083/jcb.102.6.2088</identifier><identifier>PMID: 3519621</identifier><identifier>CODEN: JCLBA3</identifier><language>eng</language><publisher>New York, NY: Rockefeller University Press</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Antibodies ; Antiserum ; Axons ; Axons - analysis ; Biological and medical sciences ; Brain ; Brain Chemistry ; Cells ; Dendrites ; Dendrites - analysis ; Erythrocytes ; Fundamental and applied biological sciences. Psychology ; Holoproteins ; Immune Sera - analysis ; Immunoenzyme Techniques ; Mice ; Neuroglia ; Neurons ; Neurons - analysis ; Organ Specificity ; Other proteins ; Proteins ; Purkinje cells ; Spectrin - immunology ; Spectrin - isolation & purification ; Synaptic Membranes - analysis</subject><ispartof>The Journal of cell biology, 1986-06, Vol.102 (6), p.2088-2097</ispartof><rights>Copyright 1986 The Rockefeller University Press</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-bf935076dee7a949ff5f97c810ca6e886f99c701740478dee3b137e0ba02ed5e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7953451$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3519621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riederer, Beat M.</creatorcontrib><creatorcontrib>Zagon, Ian S.</creatorcontrib><creatorcontrib>Goodman, Steven R.</creatorcontrib><title>Brain Spectrin(240/235) and Brain Spectrin(240/235E): Two Distinct Spectrin Subtypes with Different Locations within Mammalian Neural Cells</title><title>The Journal of cell biology</title><addtitle>J Cell Biol</addtitle><description>Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin(240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antiserum</subject><subject>Axons</subject><subject>Axons - analysis</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Chemistry</subject><subject>Cells</subject><subject>Dendrites</subject><subject>Dendrites - analysis</subject><subject>Erythrocytes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Holoproteins</subject><subject>Immune Sera - analysis</subject><subject>Immunoenzyme Techniques</subject><subject>Mice</subject><subject>Neuroglia</subject><subject>Neurons</subject><subject>Neurons - analysis</subject><subject>Organ Specificity</subject><subject>Other proteins</subject><subject>Proteins</subject><subject>Purkinje cells</subject><subject>Spectrin - immunology</subject><subject>Spectrin - isolation & purification</subject><subject>Synaptic Membranes - analysis</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1uEzEUhS0EKmlhywokLxBqF5P6d2yzQIJQClKARcva8jg2dTTjCbanVZ-Bl65LohQkVr7S-XzuuToAvMBojpGkp2vb1YHM2zlBUj4CM8wZaiRm6DGYIURwozjhT8FhzmuEEBOMHoADyrFqCZ6B3x-SCRFebJwtKcRjwtApofwEmriC_9fOTt7Cy5sRfgy5hGjLHoAXU1duNy7Dm1Cuqu69Sy4WuBytKWGMW6GCX80wmD6YCL-5KZkeLlzf52fgiTd9ds937xH48enscvG5WX4__7J4v2wso7w0nVeUI9GunBNGMeU990pYiZE1rZOy9UpZgbBg9VpZKdphKhzqDCJuxR09Au-2vpupG9zK1og1g96kMJh0q0cT9L9KDFf653itCcaMcFwN3uwM0vhrcrnoIWRbTzDRjVPWopVMCKkqON-CNo05J-f3SzDS9_XpWl8diG71fX31w6u_o-3xXV9Vf73TTbam98lEG_IeE4pT9ifgyy22zmVMD0tbjBXh9A5Gd6x2</recordid><startdate>19860601</startdate><enddate>19860601</enddate><creator>Riederer, Beat M.</creator><creator>Zagon, Ian S.</creator><creator>Goodman, Steven R.</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860601</creationdate><title>Brain Spectrin(240/235) and Brain Spectrin(240/235E): Two Distinct Spectrin Subtypes with Different Locations within Mammalian Neural Cells</title><author>Riederer, Beat M. ; Zagon, Ian S. ; Goodman, Steven R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-bf935076dee7a949ff5f97c810ca6e886f99c701740478dee3b137e0ba02ed5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antiserum</topic><topic>Axons</topic><topic>Axons - analysis</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Chemistry</topic><topic>Cells</topic><topic>Dendrites</topic><topic>Dendrites - analysis</topic><topic>Erythrocytes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Holoproteins</topic><topic>Immune Sera - analysis</topic><topic>Immunoenzyme Techniques</topic><topic>Mice</topic><topic>Neuroglia</topic><topic>Neurons</topic><topic>Neurons - analysis</topic><topic>Organ Specificity</topic><topic>Other proteins</topic><topic>Proteins</topic><topic>Purkinje cells</topic><topic>Spectrin - immunology</topic><topic>Spectrin - isolation & purification</topic><topic>Synaptic Membranes - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riederer, Beat M.</creatorcontrib><creatorcontrib>Zagon, Ian S.</creatorcontrib><creatorcontrib>Goodman, Steven R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riederer, Beat M.</au><au>Zagon, Ian S.</au><au>Goodman, Steven R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain Spectrin(240/235) and Brain Spectrin(240/235E): Two Distinct Spectrin Subtypes with Different Locations within Mammalian Neural Cells</atitle><jtitle>The Journal of cell biology</jtitle><addtitle>J Cell Biol</addtitle><date>1986-06-01</date><risdate>1986</risdate><volume>102</volume><issue>6</issue><spage>2088</spage><epage>2097</epage><pages>2088-2097</pages><issn>0021-9525</issn><eissn>1540-8140</eissn><coden>JCLBA3</coden><abstract>Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin(240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals.</abstract><cop>New York, NY</cop><pub>Rockefeller University Press</pub><pmid>3519621</pmid><doi>10.1083/jcb.102.6.2088</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of cell biology, 1986-06, Vol.102 (6), p.2088-2097 |
| issn | 0021-9525 1540-8140 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Analytical, structural and metabolic biochemistry Animals Antibodies Antiserum Axons Axons - analysis Biological and medical sciences Brain Brain Chemistry Cells Dendrites Dendrites - analysis Erythrocytes Fundamental and applied biological sciences. Psychology Holoproteins Immune Sera - analysis Immunoenzyme Techniques Mice Neuroglia Neurons Neurons - analysis Organ Specificity Other proteins Proteins Purkinje cells Spectrin - immunology Spectrin - isolation & purification Synaptic Membranes - analysis |
| title | Brain Spectrin(240/235) and Brain Spectrin(240/235E): Two Distinct Spectrin Subtypes with Different Locations within Mammalian Neural Cells |
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