Brain Spectrin(240/235) and Brain Spectrin(240/235E): Two Distinct Spectrin Subtypes with Different Locations within Mammalian Neural Cells

Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic...

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Veröffentlicht in:	The Journal of cell biology 1986-06, Vol.102 (6), p.2088-2097
Hauptverfasser:	Riederer, Beat M., Zagon, Ian S., Goodman, Steven R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Antibodies Antiserum Axons Axons - analysis Biological and medical sciences Brain Brain Chemistry Cells Dendrites Dendrites - analysis Erythrocytes Fundamental and applied biological sciences. Psychology Holoproteins Immune Sera - analysis Immunoenzyme Techniques Mice Neuroglia Neurons Neurons - analysis Organ Specificity Other proteins Proteins Purkinje cells Spectrin - immunology Spectrin - isolation & purification Synaptic Membranes - analysis
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Zusammenfassung:	Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin(240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals.
ISSN:	0021-9525 1540-8140
DOI:	10.1083/jcb.102.6.2088