Disseminated Mycobacterium tuberculosis infection due to interferon γ deficiency. Response to replacement therapy

The case of a previously healthy HIV seronegative woman with disseminated Mycobacterium tuberculosis infection and markedly reduced interferon γ production is reported here. Complete healing of her disseminated lesions was seen only after addition of subcutaneous interferon γ to her tuberculosis tre...

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Veröffentlicht in:	Thorax 2007-01, Vol.62 (1), p.97-99
Hauptverfasser:	Luke Seneviratne, Suranjith, Doffinger, Rainer, Macfarlane, John, Ceron-Gutierrez, L, Amel Kashipaz, M R, Robbins, A, Patel, T, Powell, P T, Kumararatne, D S, Powell, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Bacterial diseases Biological and medical sciences Case Report Female HIV Seronegativity - immunology Human bacterial diseases Human immunodeficiency virus Humans IFN Infectious diseases interferon Interferon-gamma - administration & dosage Interferon-gamma - deficiency Medical sciences Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Pneumology Tuberculosis - drug therapy Tuberculosis - immunology Tuberculosis and atypical mycobacterial infections
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Beschreibung
Zusammenfassung:	The case of a previously healthy HIV seronegative woman with disseminated Mycobacterium tuberculosis infection and markedly reduced interferon γ production is reported here. Complete healing of her disseminated lesions was seen only after addition of subcutaneous interferon γ to her tuberculosis treatment.
ISSN:	0040-6376 1468-3296
DOI:	10.1136/thx.2005.051649