Radiation-Induced Delay of Nuclear Pore Formation

Radiation-Induced Delay of Nuclear Pore Formation

We have shown that radiation affects the nuclear envelope, a membrane structure-closely associated with DNA. The density of nuclear pores visible on freeze-etch surfaces decreased at a rate of 0.042 (pores/mum2)/100 rad with respect to unirradiated cells. This is interpreted as a radiation-induced d...

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Veröffentlicht in:J. Cell Biol.; (United States) 1976-08, Vol.70 (2), p.466-470
Hauptverfasser: Szekely, Joseph G., Copps, Theodore P.
Format: Artikel
Sprache:eng
Schlagworte:
560121 - Radiation Effects on Cells- External Source- (-1987)
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
Brief Notes
CELL CONSTITUENTS
Cell cycle
Cell Division
Cell Line
Cell lines
CELL NUCLEI
Cell nucleus
Cell Nucleus - radiation effects
Cell Nucleus - ultrastructure
Density
Developmental delay
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
Endothelial cells
Giant cells
HeLa cells
IONIZING RADIATIONS
IRRADIATION
Membranes - radiation effects
Nuclear membrane
Radiation damage
RADIATION EFFECTS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RADIATIONS
X RADIATION
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Beschreibung
Zusammenfassung:We have shown that radiation affects the nuclear envelope, a membrane structure-closely associated with DNA. The density of nuclear pores visible on freeze-etch surfaces decreased at a rate of 0.042 (pores/mum2)/100 rad with respect to unirradiated cells. This is interpreted as a radiation-induced delay in development of the nuclear envelope.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.70.2.466