Comparison of in vitro-specific blood tests with tuberculin skin test for diagnosis of latent tuberculosis before anti-TNF therapy

Introduction:Latent tuberculosis infection (LTBI) is detected with the tuberculin skin test (TST) before anti-TNF therapy. We aimed to investigate in vitro blood assays with TB-specific antigens (CFP-10, ESAT-6), in immune-mediated inflammatory diseases (IMID) for LTBI screening.Patients and methods...

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Veröffentlicht in:	Annals of the rheumatic diseases 2007-12, Vol.66 (12), p.1610-1615
Hauptverfasser:	Sellam, Jérémie, Hamdi, Haifa, Roy, Carine, Baron, Gabriel, Lemann, Marc, Puéchal, Xavier, Breban, Maxime, Berenbaum, Francis, Humbert, Marc, Weldingh, Karin, Salmon, Dominique, Ravaud, Philippe, Emilie, Dominique, Mariette, Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antibiotics Antigens, Bacterial - metabolism Antitubercular Agents - therapeutic use Bacterial diseases Bacterial Proteins - metabolism BCG Vaccine - administration & dosage Biological and medical sciences Cells, Cultured Chi-Square Distribution Crohn Disease - drug therapy Crohn Disease - microbiology Crohn's disease Extended Report Human bacterial diseases Humans Immunologic Tests Immunosuppressive Agents - therapeutic use Infections Infectious diseases Interferon-gamma - metabolism Leukocytes, Mononuclear - metabolism Medical sciences Middle Aged Mycobacterium Mycobacterium tuberculosis Patient Selection Patients Population Recombinant Proteins - metabolism Rheumatic Diseases - drug therapy Rheumatic Diseases - microbiology ROC Curve Sensitivity and Specificity Skin Studies Substance abuse treatment Thymidine - metabolism Tuberculin Test Tuberculosis Tuberculosis - complications Tuberculosis - diagnosis Tuberculosis - drug therapy Tuberculosis and atypical mycobacterial infections Tumor Necrosis Factor-alpha - antagonists & inhibitors
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Zusammenfassung:	Introduction:Latent tuberculosis infection (LTBI) is detected with the tuberculin skin test (TST) before anti-TNF therapy. We aimed to investigate in vitro blood assays with TB-specific antigens (CFP-10, ESAT-6), in immune-mediated inflammatory diseases (IMID) for LTBI screening.Patients and methods:Sixty-eight IMID patients with (n = 35) or without (n = 33) LTBI according to clinico-radiographic findings or TST results (10 mm cutoff value) underwent cell proliferation assessed by thymidine incorporation and PKH-26 dilution assays, and IFNγ-release enzyme-linked immunosorbent spot (ELISPOT) assays with TB-specific antigens.Results:In vitro blood assays gave higher positive results in patients with LTBI than without (p0.3) and lower results than those with LTBI (p
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.2007.069799