A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometry

Background: Patients with alcohol addiction show a number of transient or persistent neurological and psychiatric deficits. The complexity of these brain alterations suggests that several brain areas are involved, although the definition of the brain alteration patterns is not yet accomplished. Aim:...

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Veröffentlicht in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2007-06, Vol.78 (6), p.610-614
Hauptverfasser: Mechtcheriakov, Sergei, Brenneis, Christian, Egger, Karl, Koppelstaetter, Florian, Schocke, Michael, Marksteiner, Josef
Format: Artikel
Sprache:eng
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Zusammenfassung:Background: Patients with alcohol addiction show a number of transient or persistent neurological and psychiatric deficits. The complexity of these brain alterations suggests that several brain areas are involved, although the definition of the brain alteration patterns is not yet accomplished. Aim: To determine brain atrophy patterns in patients with alcohol dependence. Methods: Voxel-based morphometry (VBM) of grey matter (GM) and white matter (WM) was performed in 22 patients with alcohol dependence and in 22 healthy controls matched for age and sex. Results: In patients with alcohol dependence, VBM of GM revealed a significant decrease in density (p
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2006.095869