Complement fixing antibody against solubilized placental microsomal fraction in pre-eclampsia sera

Complement fixing antibody against solubilized placental microsomal fraction in pre-eclampsia sera

Placental microsomal fraction was prepared from several term human placentae. A major composite protein (molecular weight 30,000-160,000) was separated by gel filtration of solubilized microsomal fraction. Complement fixing antibody against this protein occurred in 40% of normal pregnancy sera, and...

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Veröffentlicht in:British journal of experimental pathology 1974-12, Vol.55 (6), p.570-574
Hauptverfasser: Gaugas, J M, Curzen, P
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Antigens
Chromatography, Gel
Complement Fixation Tests
Female
Glycoproteins - analysis
Glycoproteins - immunology
Humans
Immune Sera
Isoantibodies
Isoantigens
Microsomes - immunology
Molecular Weight
Placenta - analysis
Placenta - immunology
Pre-Eclampsia - immunology
Pregnancy
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Zusammenfassung:Placental microsomal fraction was prepared from several term human placentae. A major composite protein (molecular weight 30,000-160,000) was separated by gel filtration of solubilized microsomal fraction. Complement fixing antibody against this protein occurred in 40% of normal pregnancy sera, and in 44·6% of pre-eclampsia sera.
ISSN:0007-1021