Plasma kinin formation by complexes of aggregated gamma-globulin and serum proteins

Plasma kinin formation by complexes of aggregated gamma-globulin and serum proteins

The precipitating complexes formed by heat-aggregated γ-globulin with rheumatoid factor and other serum proteins, induce kinin formation in plasma and synovial fluids. Insoluble cross-linked aggregated γ-globulin also bound and activated kinin-forming factors. Complement inhibitors did not suppress...

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Veröffentlicht in:British journal of experimental pathology 1970-06, Vol.51 (3), p.328-331
Hauptverfasser: Eisen, V, Smith, H G
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biphenyl Compounds
Blood Proteins
Bradykinin - pharmacology
Complement Inactivator Proteins
Edetic Acid - pharmacology
Female
gamma-Globulins - metabolism
Guinea Pigs
Hot Temperature
Humans
Kinins - biosynthesis
Kinins - blood
Rats
Rheumatoid Factor - metabolism
Synovial Fluid - metabolism
Uterus - drug effects
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Zusammenfassung:The precipitating complexes formed by heat-aggregated γ-globulin with rheumatoid factor and other serum proteins, induce kinin formation in plasma and synovial fluids. Insoluble cross-linked aggregated γ-globulin also bound and activated kinin-forming factors. Complement inhibitors did not suppress these actions of the complexes.
ISSN:0007-1021