Studies of Potential Radiosensitizing Agents. The Effect of 2-Methyl-1: 4-Naphthohydroquinone Diphosphate (Synkavit) on the level of Adenosine Triphosphate in Mouse Ascites Tumour
The radiosensitizing agent, Synkavit, reduces the ATP content of Ehrlich mouse ascites tumour cells in vivo at dose levels of about 1 mu Mole/gram and in vitro at concentrations between 3 x 10/sup -2/ and 3 x 10/sup -6/ molar. The higher concentration of the substance reduced the respiration, while...
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| Veröffentlicht in: | Brit. J. Cancer 1962-09, Vol.16 (3), p.460-465 |
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| container_title | Brit. J. Cancer |
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| creator | Chipperfield, Barbara Marrian, D H |
| description | The radiosensitizing agent, Synkavit, reduces the ATP content of Ehrlich mouse ascites tumour cells in vivo at dose levels of about 1 mu Mole/gram and in vitro at concentrations between 3 x 10/sup -2/ and 3 x 10/sup -6/ molar. The higher concentration of the substance reduced the respiration, while the low concentration caused a small stimulation in vitro. (auth) |
| doi_str_mv | 10.1038/bjc.1962.51 |
| format | Article |
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The Effect of 2-Methyl-1: 4-Naphthohydroquinone Diphosphate (Synkavit) on the level of Adenosine Triphosphate in Mouse Ascites Tumour</title><source>MEDLINE</source><source>Nature Journals Online</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chipperfield, Barbara ; Marrian, D H</creator><creatorcontrib>Chipperfield, Barbara ; Marrian, D H ; Cambridge Univ., Eng</creatorcontrib><description>The radiosensitizing agent, Synkavit, reduces the ATP content of Ehrlich mouse ascites tumour cells in vivo at dose levels of about 1 mu Mole/gram and in vitro at concentrations between 3 x 10/sup -2/ and 3 x 10/sup -6/ molar. The higher concentration of the substance reduced the respiration, while the low concentration caused a small stimulation in vitro. 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Cancer, 1962-09, Vol.16 (3), p.460-465</ispartof><rights>The British Empire Cancer Campaign 1962</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-be0560dbae260e423766684f5e5da1fdd9ad83d35728ed6307ccc15f30f30d33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2070966/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2070966/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2726,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14020881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4740393$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Chipperfield, Barbara</creatorcontrib><creatorcontrib>Marrian, D H</creatorcontrib><creatorcontrib>Cambridge Univ., Eng</creatorcontrib><title>Studies of Potential Radiosensitizing Agents. The Effect of 2-Methyl-1: 4-Naphthohydroquinone Diphosphate (Synkavit) on the level of Adenosine Triphosphate in Mouse Ascites Tumour</title><title>Brit. J. Cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The radiosensitizing agent, Synkavit, reduces the ATP content of Ehrlich mouse ascites tumour cells in vivo at dose levels of about 1 mu Mole/gram and in vitro at concentrations between 3 x 10/sup -2/ and 3 x 10/sup -6/ molar. The higher concentration of the substance reduced the respiration, while the low concentration caused a small stimulation in vitro. (auth)</description><subject>ADENOSINE</subject><subject>ADENOSINE TRIPHOSPHATE</subject><subject>Animals</subject><subject>ASCITES</subject><subject>ATP</subject><subject>BIOLOGY AND MEDICINE</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma</subject><subject>Carcinoma, Ehrlich Tumor</subject><subject>Diphosphates</subject><subject>Drug Resistance</subject><subject>DRUGS</subject><subject>Epidemiology</subject><subject>FLUIDS</subject><subject>METABOLISM</subject><subject>MICE</subject><subject>Molecular Medicine</subject><subject>Old Medline</subject><subject>Oncology</subject><subject>original-article</subject><subject>OXIDATION</subject><subject>QUINONES</subject><subject>Radiation-Sensitizing Agents</subject><subject>RADIOSENSITIVITY</subject><subject>REDUCTION</subject><subject>RIBONUCLEIC ACID</subject><subject>TUMORS</subject><subject>VITAMIN K</subject><subject>VITAMINS</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kk1v1DAQhiMEokvhxB0sDggEWfyROAkHpFUpH1ILiOZuee3JxtusHWJnpeVv8QdxyKqUA5Ily5pn3pl5PUnymOAlwax8s96qJak4XebkTrIgOaMpKWlxN1lgjIsUVxSfJA-838ZnhcvifnJCMkxxWZJF8usqjNqAR65B31wAG4zs0HepjfNgvQnmp7EbtNrEiF-iugV03jSgwpRA00sI7aFLyVuUpV9k34bWtQc9uB-jsc4Cem_61vm-lQHQi6uDvZZ7E14iZ1GISh3soZuEVhqs8yYm1MOtDGPRpRs9oJVXJsQm63HnxuFhcq-RnYdHx_s0qT-c12ef0ouvHz-frS5SlfEipGvAOcd6LYFyDBllBee8zJocci1Jo3Uldck0ywtaguYMF0opkjcMx6MZO03ezbL9uN6BVtGBQXaiH8xODgfhpBH_RqxpxcbtBcUFrjiPAs9mAeeDEX9GUK1y1kb7RFZkmFVTlefHKpNr4IPYGa-g66SFOLsoGaGUV0UEX82gGpz3AzQ3nRAspkUQcRHEtAgiJ5F-crv5v-zx5yPwegZ8DNkNDGIbrbXRz__oPZ1xK8M4wI1eZCYkEr8BGMHLuQ</recordid><startdate>19620901</startdate><enddate>19620901</enddate><creator>Chipperfield, Barbara</creator><creator>Marrian, D H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19620901</creationdate><title>Studies of Potential Radiosensitizing Agents. The Effect of 2-Methyl-1: 4-Naphthohydroquinone Diphosphate (Synkavit) on the level of Adenosine Triphosphate in Mouse Ascites Tumour</title><author>Chipperfield, Barbara ; Marrian, D H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-be0560dbae260e423766684f5e5da1fdd9ad83d35728ed6307ccc15f30f30d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>ADENOSINE</topic><topic>ADENOSINE TRIPHOSPHATE</topic><topic>Animals</topic><topic>ASCITES</topic><topic>ATP</topic><topic>BIOLOGY AND MEDICINE</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma</topic><topic>Carcinoma, Ehrlich Tumor</topic><topic>Diphosphates</topic><topic>Drug Resistance</topic><topic>DRUGS</topic><topic>Epidemiology</topic><topic>FLUIDS</topic><topic>METABOLISM</topic><topic>MICE</topic><topic>Molecular Medicine</topic><topic>Old Medline</topic><topic>Oncology</topic><topic>original-article</topic><topic>OXIDATION</topic><topic>QUINONES</topic><topic>Radiation-Sensitizing Agents</topic><topic>RADIOSENSITIVITY</topic><topic>REDUCTION</topic><topic>RIBONUCLEIC ACID</topic><topic>TUMORS</topic><topic>VITAMIN K</topic><topic>VITAMINS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chipperfield, Barbara</creatorcontrib><creatorcontrib>Marrian, D H</creatorcontrib><creatorcontrib>Cambridge Univ., Eng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brit. J. Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chipperfield, Barbara</au><au>Marrian, D H</au><aucorp>Cambridge Univ., Eng</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies of Potential Radiosensitizing Agents. The Effect of 2-Methyl-1: 4-Naphthohydroquinone Diphosphate (Synkavit) on the level of Adenosine Triphosphate in Mouse Ascites Tumour</atitle><jtitle>Brit. J. Cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1962-09-01</date><risdate>1962</risdate><volume>16</volume><issue>3</issue><spage>460</spage><epage>465</epage><pages>460-465</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>The radiosensitizing agent, Synkavit, reduces the ATP content of Ehrlich mouse ascites tumour cells in vivo at dose levels of about 1 mu Mole/gram and in vitro at concentrations between 3 x 10/sup -2/ and 3 x 10/sup -6/ molar. The higher concentration of the substance reduced the respiration, while the low concentration caused a small stimulation in vitro. (auth)</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14020881</pmid><doi>10.1038/bjc.1962.51</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| source | MEDLINE; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | ADENOSINE ADENOSINE TRIPHOSPHATE Animals ASCITES ATP BIOLOGY AND MEDICINE Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma Carcinoma, Ehrlich Tumor Diphosphates Drug Resistance DRUGS Epidemiology FLUIDS METABOLISM MICE Molecular Medicine Old Medline Oncology original-article OXIDATION QUINONES Radiation-Sensitizing Agents RADIOSENSITIVITY REDUCTION RIBONUCLEIC ACID TUMORS VITAMIN K VITAMINS |
| title | Studies of Potential Radiosensitizing Agents. The Effect of 2-Methyl-1: 4-Naphthohydroquinone Diphosphate (Synkavit) on the level of Adenosine Triphosphate in Mouse Ascites Tumour |
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