Studies of Potential Radiosensitizing Agents. The Effect of 2-Methyl-1: 4-Naphthohydroquinone Diphosphate (Synkavit) on the level of Adenosine Triphosphate in Mouse Ascites Tumour

The radiosensitizing agent, Synkavit, reduces the ATP content of Ehrlich mouse ascites tumour cells in vivo at dose levels of about 1 mu Mole/gram and in vitro at concentrations between 3 x 10/sup -2/ and 3 x 10/sup -6/ molar. The higher concentration of the substance reduced the respiration, while...

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Veröffentlicht in:	Brit. J. Cancer 1962-09, Vol.16 (3), p.460-465
Hauptverfasser:	Chipperfield, Barbara, Marrian, D H
Format:	Artikel
Sprache:	eng
Schlagworte:	ADENOSINE ADENOSINE TRIPHOSPHATE Animals ASCITES ATP BIOLOGY AND MEDICINE Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma Carcinoma, Ehrlich Tumor Diphosphates Drug Resistance DRUGS Epidemiology FLUIDS METABOLISM MICE Molecular Medicine Old Medline Oncology original-article OXIDATION QUINONES Radiation-Sensitizing Agents RADIOSENSITIVITY REDUCTION RIBONUCLEIC ACID TUMORS VITAMIN K VITAMINS
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Zusammenfassung:	The radiosensitizing agent, Synkavit, reduces the ATP content of Ehrlich mouse ascites tumour cells in vivo at dose levels of about 1 mu Mole/gram and in vitro at concentrations between 3 x 10/sup -2/ and 3 x 10/sup -6/ molar. The higher concentration of the substance reduced the respiration, while the low concentration caused a small stimulation in vitro. (auth)
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.1962.51