The nature and identification of quantitative trait loci: a community's view

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways,...

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Veröffentlicht in:	Nature reviews. Genetics 2003-11, Vol.4 (11), p.911-916
Hauptverfasser:	Abiola, Oduola, Angel, Joe M, Avner, Philip, Bachmanov, Alexander A, Belknap, John K, Bennett, Beth, Blankenhorn, Elizabeth P, Blizard, David A, Bolivar, Valerie, Brockmann, Gundrun A, Buck, Kari J, Bureau, Jean-Francoise, Casley, William L, Chesler, Elissa J, Cheverud, James M, Churchill, Gary A, Cook, Melloni, Crabbe, John C, Crusio, Wim E, Darvasi, Ariel, de Haan, Gerald, Dermant, Peter, Doerge, R W, Elliot, Rosemary W, Farber, Charles R, Flaherty, Lorraine, Flint, Jonathan, Gershenfeld, Howard, Gibson, John P, Gu, Jing, Gu, Weikuan, Himmelbauer, Heinz, Hitzemann, Robert, Hsu, Hui-Chen, Hunter, Kent, Iraqi, Fuad F, Jansen, Ritsert C, Johnson, Thomas E, Jones, Byron C, Kempermann, Gerd, Lammert, Frank, Lu, Lu, Manly, Kenneth F, Matthews, Douglas B, Medrano, Juan F, Mehrabian, Margarete, Mittlemann, Guy, Mock, Beverly A, Mogil, Jeffrey S, Montagutelli, Xavier, Morahan, Grant, Mountz, John D, Nagase, Hiroki, Nowakowski, Richard S, O'Hara, Bruce F, Osadchuk, Alexander V, Paigen, Beverly, Palmer, Abraham A, Peirce, Jeremy L, Pomp, Daniel, Rosemann, Michael, Rosen, Glenn D, Schalkwyk, Leonard C, Seltzer, Ze'ev, Settle, Stephen, Shimomura, Kazuhiro, Shou, Siming, Sikela, James M, Siracusa, Linda D, Spearow, Jimmy L, Teuscher, Cory, Threadgill, David W, Toth, Linda A, Toye, Ayo A, Vadasz, Csaba, Van Zant, Gary, Wakeland, Edward, Williams, Robert W, Zhang, Huang-Ge, Zou, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal genetics Animal Genetics and Genomics Animals Animals, Genetically Modified Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Chromosome Mapping - standards Diverse techniques Fundamental and applied biological sciences. Psychology Gene Function Genetics guidelines-2 Human Genetics Humans Life Sciences Molecular and cellular biology Quantitative Trait Loci Space life sciences
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Zusammenfassung:	This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?
ISSN:	1471-0056 1471-0064
DOI:	10.1038/nrg1206