The relationship between extracellular lactate and tumour pH in a murine tumour model of ischaemia-reperfusion

We have studied the relationship between extracellular lactate (LACTe) and extracellular pH (pHe) in murine tumours after vascular occlusion (clamping) followed by reperfusion. In tumours occluded at ambient room temperature, LACTe, measured by microdialysis, increased linearly with time and correla...

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Veröffentlicht in:	British journal of cancer 1997-01, Vol.75 (3), p.319-323
Hauptverfasser:	PARKINS, C. S, STRATFORD, M. R. L, DENNIS, M. F, STUBBS, M, CHAPLIN, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood supply Adenocarcinoma - metabolism Adenocarcinoma - physiopathology Animals Biological and medical sciences Extracellular Space Female General aspects (metabolism, cell proliferation, established cell line...) Hydrogen-Ion Concentration Ischemia Kinetics Lactates - metabolism Mammary Neoplasms, Experimental - blood supply Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - physiopathology Medical sciences Mice Mice, Inbred CBA Reperfusion Time Factors Tumor cell Tumors
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Zusammenfassung:	We have studied the relationship between extracellular lactate (LACTe) and extracellular pH (pHe) in murine tumours after vascular occlusion (clamping) followed by reperfusion. In tumours occluded at ambient room temperature, LACTe, measured by microdialysis, increased linearly with time and correlated strongly with the acidification of the extracellular compartment (r=0.97, P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.1997.53