DOES PIRENZEPINE DISTINGUISH BETWEEN ‘SUBTYPES’ OF MUSCARINIC RECEPTORS?

Pharmacological studies with pirenzepine were carried out on the isolated ileum and atrium of the guinea‐pig and on the acid secretion from the isolated stomach of the mouse. Pirenzepine inhibited the bethanechol‐evoked changes in all three organs in a dose‐dependent manner. The slopes of the Schild...

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Veröffentlicht in:	British journal of pharmacology 1982-12, Vol.77 (4), p.567-569
1. Verfasser:	SZELENYI, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine - pharmacology Benzodiazepinones - pharmacology Bethanechol Compounds - pharmacology Gastric Mucosa - drug effects Gastric Mucosa - metabolism Guinea Pigs In Vitro Techniques Mice Muscle, Smooth - drug effects Myocardial Contraction - drug effects Pirenzepine Receptors, Cholinergic - drug effects Receptors, Muscarinic - classification Receptors, Muscarinic - drug effects
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Beschreibung
Zusammenfassung:	Pharmacological studies with pirenzepine were carried out on the isolated ileum and atrium of the guinea‐pig and on the acid secretion from the isolated stomach of the mouse. Pirenzepine inhibited the bethanechol‐evoked changes in all three organs in a dose‐dependent manner. The slopes of the Schild‐plots confirmed the competitive nature of the antagonism by pirenzepine. The estimated pA2‐values were very similar. Based on these data, it might be concluded that pirenzepine is an anticholinoceptor compound without specific affinity for gastric muscarinic receptors.
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1982.tb09332.x