ANTICOAGULANT EFFECTS OF SULPHATED POLYSACCHARIDES IN NORMAL AND ANTITHROMBIN III‐DEFICIENT PLASMAS

1 Comparison of the effects of sulphated polysaccharides on thrombin‐induced clotting of normal and antithrombin III‐deficient plasmas suggests the involvement of antithrombin III (AT III) in the anticoagulant activities of cellulose, dextran and xylan sulphates. 2 AT III appears to play little or n...

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Veröffentlicht in:	British journal of pharmacology 1980-08, Vol.69 (4), p.675-677
Hauptverfasser:	KINDNESS, G., LONG, W.F., WILLIAMSON, F.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants Antithrombin III Deficiency Blood Coagulation - drug effects Carrageenan - pharmacology Cellulose - pharmacology Dermatan Sulfate - pharmacology Dextrans - pharmacology Glycosaminoglycans - pharmacology Heparin - pharmacology Humans Thrombin Time Xylans - pharmacology
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Beschreibung
Zusammenfassung:	1 Comparison of the effects of sulphated polysaccharides on thrombin‐induced clotting of normal and antithrombin III‐deficient plasmas suggests the involvement of antithrombin III (AT III) in the anticoagulant activities of cellulose, dextran and xylan sulphates. 2 AT III appears to play little or no role in the anticoagulant activity of carrageenans.
ISSN:	0007-1188 1476-5381
DOI:	10.1111/j.1476-5381.1980.tb07921.x