THE EFFECT OF CONDITIONS INFLUENCING ENDOGENOUS PROSTAGLANDINS ON THE ACTIVITY OF Δ′‐TETRAHYDROCANNABINOL IN MICE

1 The cataleptic effect of Δ′‐tetrahydrocannabinol (THC) depends upon the availability of the precursors of prostaglandins and the response is reduced in mice maintained on a diet deficient in arachidonic acid (AA) and restored by exogenous AA given intraperitoneally, or by feeding a normal diet. 2 In yeast‐induced fever, which is accompanied by an increase in the synthesis of prostaglandins, THC shows an enhanced cataleptic effect. 3 Exposure to cold which results in depletion of prostaglandins reduces the effect of THC.