COMPARISON OF PHARMACOLOGICAL AND BINDING ASSAYS FOR TEN β‐ADRENOCEPTOR BLOCKING AGENTS AND TWO β‐ADRENOCEPTOR AGONISTS

1 The inhibition constants evaluated by binding assays for ten β‐adrenoceptor blocking agents and two β‐adrenoceptor agonists, were compared with the pA2 and pD2 values determined in vitro and in vivo. 2 There was only a limited correlation between β1 or β2 selectivities observed with the different methods. 3 Selectivity is generally less pronounced in binding assays than for in vivo and in vitro experiments.