A comparison of the effects of fluvastatin and bezafibrate on exercise metabolism: a placebo‐controlled study in healthy normolipidaemic subjects

1We have examined the interaction between aerobic exercise and lipid‐lowering drugs in a crossover study of 16 healthy normolipidaemic volunteers who each received 21 days' treatment with bezafibrate (400 mg), fluvastatin (40 mg), and placebo, in random order. 2Fluvastatin treatment reduced pre...

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Veröffentlicht in:	British journal of clinical pharmacology 1996-05, Vol.41 (5), p.381-387
Hauptverfasser:	EAGLES, C. J., KENDALL, M. J., MAXWELL, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance bezafibrate Bezafibrate - blood Bezafibrate - pharmacology Cross-Over Studies Double-Blind Method Energy Metabolism - drug effects exercise Exercise - physiology fat oxidation Fatty Acids, Monounsaturated - blood Fatty Acids, Monounsaturated - pharmacology Fatty Acids, Nonesterified - metabolism Female Fluvastatin Humans Hydroxymethylglutaryl CoA Reductases - blood Hydroxymethylglutaryl CoA Reductases - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypolipidemic Agents - blood Hypolipidemic Agents - pharmacology Indoles - blood Indoles - pharmacology Male Original Oxidation-Reduction
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Beschreibung
Zusammenfassung:	1We have examined the interaction between aerobic exercise and lipid‐lowering drugs in a crossover study of 16 healthy normolipidaemic volunteers who each received 21 days' treatment with bezafibrate (400 mg), fluvastatin (40 mg), and placebo, in random order. 2Fluvastatin treatment reduced pre‐exercise total cholesterol (TC) by 23% (P
ISSN:	0306-5251 1365-2125
DOI:	10.1046/j.1365-2125.1996.03415.x